Franziska Gsottberger

Aug 25, 2023 | nature.com | Franziska Gsottberger |Scott Parker |Kerstin Wendland |Rebekka George |Gloria Lutzny-Geier

AbstractCellular stress responses including the unfolded protein response (UPR) decide over the fate of an individual cell to ensure survival of the entire organism. During physiologic UPR counter-regulation, protective proteins are upregulated to prevent cell death. A similar strategy induces resistance to UPR in cancer. Therefore, we hypothesized that blocking protein synthesis following induction of UPR substantially enhances drug-induced apoptosis of malignant cells.