Kerstin Wendland

Aug 25, 2023 | nature.com | Franziska Gsottberger |Scott Parker |Kerstin Wendland |Rebekka George |Gloria Lutzny-Geier

AbstractCellular stress responses including the unfolded protein response (UPR) decide over the fate of an individual cell to ensure survival of the entire organism. During physiologic UPR counter-regulation, protective proteins are upregulated to prevent cell death. A similar strategy induces resistance to UPR in cancer. Therefore, we hypothesized that blocking protein synthesis following induction of UPR substantially enhances drug-induced apoptosis of malignant cells.

Apr 21, 2023 | nature.com | Urs Mörbe |Kerstin Wendland |Katarzyna M. Sitnik |Allan McI Mowat |Eugene C Butcher |Søren Brunak | +2 more

AbstractThe intestinal lamina propria contains a diverse network of fibroblasts that provide key support functions to cells within their local environment. Despite this, our understanding of the diversity, location and ontogeny of fibroblasts within and along the length of the intestine remains incomplete. Here we show that the small and large intestinal lamina propria contain similar fibroblast subsets that locate in specific anatomical niches.