Fred Gage

Dec 9, 2024 | nature.com | Paola Arlotta |Helen S. Bateup |J. Gray Camp |Silvia Cappello |Fred Gage |Jürgen A. Knoblich | +13 more

AbstractAs the field of neural organoids and assembloids rapidly expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models.

Dec 8, 2024 | onlinelibrary.wiley.com | Fred Gage

Conflicts of Interest The author declares no conflicts of interest. References , and . 1967. “Postnatal Neurogenesis in the Guinea-Pig.” Nature 214, no. 5093: 1098–1101. https://doi.org/10.1038/2141098a0. , and . 1985. “Neural Grafting in Animal Models of Neurodegenerative Diseases.” Annals of the New York Academy of Sciences 457: 53–81. 2024. “From Inhibition to Exciting Science.” Hippocampus. https://doi.org/10.1002/hipo.23659. , and . 1999.

Feb 1, 2024 | nature.com | Jeffrey Jones |Fred Gage

AbstractSchizophrenia (SZ) is a serious mental illness and neuropsychiatric brain disorder with behavioral symptoms that include hallucinations, delusions, disorganized behavior, and cognitive impairment. Regulation of such behaviors requires utilization of neurotransmitters released to mediate cell-cell communication which are essential to brain functions in health and disease. We hypothesized that SZ may involve dysregulation of neurotransmitters secreted from neurons.

Mar 6, 2023 | biologicalpsychiatryjournal.com | Paola Arlotta |Fred Gage

Progress in understanding the molecular mechanisms underlying human psychiatric disease has been hampered by a lack of models that can reflect the genetic states underlying human cognitive disease and species-specific differences in brain development and function.