Fumiyuki Nakagawa

Aug 19, 2024 | biorxiv.org | Miho Tanaka |Takahiko Toyonaga |Fumiyuki Nakagawa |Takeo Iwamoto

AbstractBackground: Dietary components and their metabolites produced by intestinal bacteria play a crucial role in maintaining intestinal epithelial integrity. Disrupted epithelial integrity increases permeability and leads to chronic inflammation in the colon, known as ulcerative colitis (UC), in genetically predisposed individuals. However, the gut microbial metabolites regulating epithelial permeability remain unexplored and their metabolism in UC patients is unclear.