Gaetane Nocturne

Sep 27, 2024 | biorxiv.org | Loic Meudec |Xavier Mariette |Gaetane Nocturne |Ilya Gurevic

AbstractObjective: Our objective was to define the effect of JAK1/2 inhibitor (JAKinib) withdrawal on JAK/STAT biochemical response in the context of systemic rheumatic diseases. Methods: We tested Type I (bind kinase active conformation) and Type II (bind kinase inactive conformation) JAKinibs in vitro using mesenchymal stromal cells and endothelial cells. We translated our findings in vivo studying NK cells from rheumatoid arthritis (RA) patients treated with Type I JAKinibs or methotrexate.

Aug 5, 2023 | acrjournals.onlinelibrary.wiley.com | Gaetane Nocturne |Assistance Publique |Hôpital Bicêtre |Xavier Mariette

INITIAL EVALUATION AND DIAGNOSIS Sjögren's disease (or Sjögren's) (1) is a systemic autoimmune disease characterized by chronic inflammation of the lacrimal and salivary glands resulting in ocular and oral dryness. In addition to dryness, most patients present with fatigue and diffuse pain. This triad of dryness, pain, and fatigue is characteristic of the disease.