Gang Du

Apr 10, 2024 | nature.com | Gang Du |Liam Healy |Liron David |Caitlin Walker |Tarick J. El-Baba |Corinne A. Lutomski | +12 more

AbstractGasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis downstream of inflammasome activation and was previously shown to form large transmembrane pores upon cleavage by inflammatory caspases to generate the GSDMD N-terminal domain (GSDMD-NT)1-10. Here we report that GSDMD Cys191 is S-palmitoylated and palmitoylation is required for pore formation.