Garry P. Nolan

Aug 31, 2023 | nature.com | Yury Goltsev |Garry P. Nolan

Co-detection by indexing (CODEX) is a recently developed and commercially available (Akoya Biosciences) technique of highly multiplexed tissue imaging — visualizing up to 60 markers at the single-cell level1,2. It belongs to a set of re-iterative fluorescent tissue imaging methods.

Jul 19, 2023 | nature.com | John Hickey |Winston R. Becker |Chenchen Zhu |Derek Chen |Daniel Cotter |Annika K Weimer | +10 more

AbstractThe intestine is a complex organ that promotes digestion, extracts nutrients, participates in immune surveillance, maintains critical symbiotic relationships with microbiota and affects overall health1. The intesting has a length of over nine metres, along which there are differences in structure and function2. The localization of individual cell types, cell type development trajectories and detailed cell transcriptional programs probably drive these differences in function.