Yury Goltsev

Oct 30, 2024 | nature.com | Johanna Klughammer |Daniel L. Abravanel |Timothy R. Blosser |Yury Goltsev |Chiara Caraccio |Nicole Cullen | +7 more

AbstractAlthough metastatic disease is the leading cause of cancer-related deaths, its tumor microenvironment remains poorly characterized due to technical and biospecimen limitations. In this study, we assembled a multi-modal spatial and cellular map of 67 tumor biopsies from 60 patients with metastatic breast cancer across diverse clinicopathological features and nine anatomic sites with detailed clinical annotations.

Aug 31, 2023 | nature.com | Yury Goltsev |Garry P. Nolan

Co-detection by indexing (CODEX) is a recently developed and commercially available (Akoya Biosciences) technique of highly multiplexed tissue imaging — visualizing up to 60 markers at the single-cell level1,2. It belongs to a set of re-iterative fluorescent tissue imaging methods.