Gary S. Nichol

Oct 17, 2024 | pubs.acs.org | Nicole A Fohn |Yuan Gao |Stephen Sproules |Gary S. Nichol

1. IntroductionClick to copy section linkSection link copied!A biphenyl motif is a core component in applications as diverse as atropisomeric ligands, switches, sensors, light-emitting diodes, and liquid crystals. Homocoupling of aryl halides provides a simple route to symmetrical biphenyls, (1) and in 1971, Semmelhack reported the first nickel-based methodology to achieve this.

Sep 9, 2024 | pubs.rsc.org | Kieran Nicholson |Sarah L McOnie |Thomas Langer |Gary S. Nichol

Borane-catalysed C2-selective indole reductive functionalisation† Indolines are common motifs within pharamceuticals and natural products. Boron catalysis enables the chemoselective allylation of indoles to give allylic indolines in excellent diastereoselectivity. Mechanistic studies revealed in situ formation of the allylic borane, allylation of the imine tautomer of the indole and B–N/B–H transborylation for catalytic turnover.