Gautam Sethi

Feb 25, 2024 | nature.com | Basappa Basappa |Tao Zhu |Gautam Sethi |Peter E. Lobie

AbstractTherapeutic targeting of KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) has remained a significant challenge in clinical oncology. Direct targeting of KRAS has proven difficult, and inhibition of the KRAS effectors have shown limited success due to compensatory activation of survival pathways. Being a core downstream effector of the KRAS-driven p44/42 MAPK and PI3K/AKT pathways governing intrinsic apoptosis, BAD phosphorylation emerges as a promising therapeutic target.

Jan 11, 2024 | nature.com | Gautam Sethi

AbstractExtracellular vesicles (EVs) have gained increasing recognition as significant regulators of intercellular communication in various physiological and pathological processes. These vesicles play a pivotal role in cancer progression by facilitating the transfer of diverse cargoes, including lipids, proteins, and nucleic acids.

Aug 25, 2023 | scholarsarchive.byu.edu | Gautam Sethi

Home > Engineering > Civil and Environmental Engineering > iEMSs Conference > 2020 > STREAM-E > 18 Keywords Climate Change, SDG #16, Indices, Weighting, Conflict, Uganda DOWNLOADS COinS Sep 15th, 12:00 PM Sep 15th, 12:20 PM Climate Change as a Threat Multiplier: Assessing Conflict Risk in Uganda Resource and income insecurity are linked to the occurrence of violent conflict, and are expected to worsen under projected climate change, signifying the need for climate-conflict assessment tools...

Jun 7, 2023 | scholarsarchive.byu.edu | Gautam Sethi

Climate Change; Fossil Fuels; Lobbying; Campaign Finance ReformRecent congressional policy outcomes on fossil fuel regulation do not reflect any urgency to curb CO2 emissions. One reason why the United States Congress has failed to enact meaningful policy to address climate change is that the fossil fuel industry, through hefty campaign contributions, is able to influence legislators to vote against environmental interests.