Geng-Min Lin

Nov 15, 2023 | nature.com | Geng-Min Lin |Christopher A. Voigt

AbstractHigh-value terpenoids are found in plants, animals and microbes, with applications spanning health to agriculture. However, moving their biosynthetic pathways to a new host is challenging when cytochrome P450 (CYP) enzymes are needed for function. Here we engineer Escherichia coli to facilitate discovery by introducing 31 recombinant genes that enhance precursor supply, combine electron transfer pathways and implement regulatory control.