Christopher A. Voigt

Nov 11, 2024 | nature.com | Yunxin Xu |Boxue Tian |Haipeng Gong |David R. Liu |Christopher A. Voigt |B. W. Thuronyi

AbstractDesigning proteins with improved functions requires a deep understanding of how sequence and function are related, a vast space that is hard to explore. The ability to efficiently compress this space by identifying functionally important features is extremely valuable. Here we establish a method called EvoScan to comprehensively segment and scan the high-fitness sequence space to obtain anchor points that capture its essential features, especially in high dimensions.

Aug 7, 2024 | onlinelibrary.wiley.com | Weize Yuan |Christopher A. Voigt |Di Sheng Lee

1 Introduction Melanins are polymers that absorb broad spectra of light, making them appear black.[1, 2] Natural melanins are biosynthesized from free tyrosine (Y), which is converted into various monomeric units that spontaneously polymerize into melanin. Various melanins protect all kingdoms of life against ultraviolet (UV) light and other stresses.

Aug 7, 2024 | pericles.pericles-prod.literatumonline.com | Di Sheng Lee |Weize Yuan |Christopher A. Voigt

1 Introduction Melanins are polymers that absorb broad spectra of light, making them appear black.[1, 2] Natural melanins are biosynthesized from free tyrosine (Y), which is converted into various monomeric units that spontaneously polymerize into melanin. Various melanins protect all kingdoms of life against ultraviolet (UV) light and other stresses.

Jun 30, 2024 | dx.doi.org | Yonatan Chemla |Connor Sweeney |Christopher Wozniak |Christopher A. Voigt

Engineering Bacteria for Environmental Release: Regulatory Challenges and Design Strategies Yonatan Chemla , Connor J Sweeney, Christopher A Wozniak, Christopher A Voigt Yonatan Chemla Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology Author Profile Connor J Sweeney Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology Christopher A Wozniak Office of Pesticide Programs, U.S. Environmental...

Nov 15, 2023 | nature.com | Geng-Min Lin |Christopher A. Voigt

AbstractHigh-value terpenoids are found in plants, animals and microbes, with applications spanning health to agriculture. However, moving their biosynthetic pathways to a new host is challenging when cytochrome P450 (CYP) enzymes are needed for function. Here we engineer Escherichia coli to facilitate discovery by introducing 31 recombinant genes that enhance precursor supply, combine electron transfer pathways and implement regulatory control.