Geoffrey Schiebinger

Dec 5, 2024 | nature.com | Hojun Li |Katie Frenis |Mayuri Tanaka-Yano |Giuseppe Tarantino |Vincent L. Butty |Marcelo Falchetti | +7 more

AbstractOver a lifetime, hematopoietic stem cells (HSCs) adjust their lineage output to support age-aligned physiology. In model organisms, stereotypic waves of hematopoiesis have been observed corresponding to defined age-biased HSC hallmarks. However, how the properties of hematopoietic stem and progenitor cells change over the human lifespan remains unclear.

Oct 11, 2023 | biorxiv.org | Becca Bonham-Carter |Geoffrey Schiebinger

AbstractWe identify a fundamental statistical phenomenon in single-cell time courses with clone-based lineage tracing. Through simple probabilistic arguments, we show how the relative growth rates of cells influence the probability that they will be sampled in clones observed across multiple time points.

Jul 23, 2023 | biorxiv.org | Geoffrey Schiebinger |Becca Bonham-Carter

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