Georg Mohr

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Mechanisms used for cDNA synthesis and site-specific integration of RNA into DNA genomes by a reverse transcriptase-Cas1 fusion protein

Apr 12, 2024 | science.org | Melad Henis |Najeeb U Siddiqui |Rachith Aiyappa |Georg Mohr

Research ArticleMOLECULAR BIOLOGYGeorg Mohr https://orcid.org/0000-0002-6411-0685, Jun Yao https://orcid.org/0000-0002-1232-1587, [...] , Seung Kuk Park https://orcid.org/0000-0003-3795-1347, Laura Markham https://orcid.org/0009-0006-7339-986X, and Alan M.
Mechanisms used for cDNA synthesis and site-specific integration of RNA into DNA genomes by a reverse transcriptase-Cas1 fusion protein

Sep 3, 2023 | biorxiv.org | Georg Mohr |Jun Yao |Seung Park |Laura Markham

AbstractReverse transcriptase-Cas1 (RT-Cas1) fusion proteins found in some CRISPR systems enable spacer acquisition from both RNA and DNA, but the mechanism of RNA spacer acquisition has remained unclear.

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