George C Tsokos

Nov 17, 2024 | nature.com | George C Tsokos

During the past year, four studies have reported ten mutations in UNC93B1, which encodes the Toll-like receptor (TLR) chaperone protein UNC93B1. All variants increased TLR7 and TLR8 signalling and caused systemic lupus erythematosus in young individuals, and highlight the therapeutic potential of targeting TLR7 and TLR8 in this disease.

Jul 15, 2024 | nature.com | George C Tsokos

AbstractUnderstanding the pathogenesis and clinical manifestations of systemic lupus erythematosus (SLE) has been a great challenge. Reductionist approaches to understand the nature of the disease have identified many pathogenetic contributors that parallel clinical heterogeneity.

Nov 23, 2023 | nature.com | George C Tsokos

Correction to: Nature Reviews Nephrology https://doi.org/10.1038/s41581-023-00786-x, published online 20 November 2023. In the originally published version of this article, the first name of Yushiro Endo was misspelled (Ushiro) and has been corrected in the HTML and PDF versions of the article. About this articleTsokos, G.C., Boulougoura, A., Kasinath, V. et al. Author Correction: The immunoregulatory roles of non-haematopoietic cells in the kidney. Nat Rev Nephrol (2023).

Nov 20, 2023 | nature.com | George C Tsokos

AbstractThe deposition of immune complexes, activation of complement and infiltration of the kidney by cells of the adaptive and innate immune systems have long been considered responsible for the induction of kidney damage in autoimmune, alloimmune and other inflammatory kidney diseases. However, emerging findings have highlighted the contribution of resident immune cells and of immune molecules expressed by kidney-resident parenchymal cells to disease processes.

Sep 22, 2023 | nature.com | Xu Jiang |George C Tsokos

AbstractInhibitory immune receptors set thresholds for immune cell activation, and their deficiency predisposes a person to autoimmune responses. However, the agonists of inhibitory immune receptors remain largely unknown, representing untapped sources of treatments for autoimmune diseases.