Xu Jiang

Dec 13, 2023 | onlinelibrary.wiley.com | Xu Jiang |Kai Xie |Hongyu Chen |Kai Zhang

Introduction Osteoarthritis (OA) is a significant cause of pain and disability in older populations, with variations in lowerlimb morphological parameters affecting weight-loading joints and leading to imbalanced mechanical loading, local stress concentration, cartilage wear, and ultimately OA progression.1-7 Studies show that morphological and structural variations in the hip joint closely relate to hip OA development, and morphological characteristics of the pelvis and hip joint relate to...

Dec 4, 2023 | nature.com | Xu Jiang

AbstractOsteoarthritis (OA) is the most common degenerative joint disease. Currently, no satisfactory pharmacological treatment exists for OA. The potential anti-inflammatory properties of Dihydrotanshinone I (DHT) have been reported, but its effects on OA are unclear. In this study, we assess the impact of DHT on the viability of human chondrocytes in vitro. We then use a guinea pig model to investigate the effects of DHT on knee osteoarthritis progression.

Oct 15, 2023 | onlinelibrary.wiley.com | Wei Luo |Engineering Shaanxi |Xu Jiang |Yi Liu

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202305453-sup-0001-SuppMat.pdf1.3 MB Supporting Information References 1, , , Adv. Funct. Mater. 2020, 30, 2000883. 2, , , Adv. Sci. 2022, 9, 2105553 3, , , , , J. Mater. Sci. Technol. 2022, 112, 329. 4, , , , , , Adv. Funct. Mater. 2023, 33, 2210578. 5, , , , , , , , Small 2021, 17, 2100970. 6, , , , , , , Composites, Part B 2018, 137, 260.

Sep 22, 2023 | nature.com | Xu Jiang |George C Tsokos

AbstractInhibitory immune receptors set thresholds for immune cell activation, and their deficiency predisposes a person to autoimmune responses. However, the agonists of inhibitory immune receptors remain largely unknown, representing untapped sources of treatments for autoimmune diseases.