George Janes

Dec 2, 2024 | progress.org.uk | Joanne Delange |George Janes

Genetic and molecular changes occurring during ovarian ageing have been mapped to single-cell resolution. Using four ovaries from young women (23-29 years old) and four from reproductively-aged women (49-54 years old), researchers investigated gene expression and chromosome structure changes during ovarian ageing.

Jan 15, 2024 | progress.org.uk | Hannah Flynn |George Janes

Alcohol's effect on sperm DNA has been shown to persist for at least one month after stopping exposure, in mice. While the focus of alcohol's impact on fertility and fetal development has mainly been on women, recent research has increasingly revealed the role of environmental stressors on sperm DNA, particularly its epigenetics. The mechanisms underpinning these changes, and the length of the impact of these stressors on the sperm an individual produces has not been clarified.

Jul 24, 2023 | progress.org.uk | Hannah Flynn |George Janes

Proteins that exist in the junctions between cells have been shown to help create signalling gradients crucial for cell differentiation in human embryo models. As cells divide and grow in a developing embryo, they differentiate to take on specific roles or identities. This must happen in the right places at the right times for the body to form appropriately.

May 22, 2023 | progress.org.uk | Joanne Delange |George Janes

Embryos have been grown in the lab for up to 25 days, the longest recorded in primates. Until now, scientists have been unable to grow primate embryos in the lab for more than a couple of weeks, with the embryos not developing much beyond the blastocyst stage. Now, two separate research labs in China have shown how the embryos can be grown outside the uterus, for up to 25 days, enabling the observation of more advanced developmental milestones. '...

May 21, 2023 | biorxiv.org | George Janes |Daniele Avitabile |John King |Simon Bellows

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