George M. Burslem

2 weeks ago | cell.com | Stephanie E Sansbury |Yevgeniy V. Serebrenik |Tomer Lapidot |David SMith |David Smith |George M. Burslem | +1 more

Keywordspooled taggingproteostasisin situ sequencingprotein misfoldingprotein localizationhydrophobic targetingIntroductionLarge-scale multiplexed imaging and gene perturbation technologies have transformed mammalian cell biology but are predominantly limited to nucleic acids. This is due to the ease of generating specific targeting reagents via sequence complementarity, which does not extend to the proteins.

Nov 15, 2023 | pubs.rsc.org | Prakash Kannaboina |George M. Burslem |Adam Green

Lead-oriented synthesis of epigenetic relevant scaffolds† A simple and rational method to rank lead-likeness of molecules using continuous evaluation functions was hereby developed. This strategy proved to be competitive against known methods and finally helped in driving synthetic efforts towards candidates of interest for epigenetic applications against HDAC6, BRD4 and EZH2.