Stephanie E Sansbury

2 weeks ago | cell.com | Stephanie E Sansbury |Yevgeniy V. Serebrenik |Tomer Lapidot |David SMith |David Smith |George M. Burslem | +1 more

Keywordspooled taggingproteostasisin situ sequencingprotein misfoldingprotein localizationhydrophobic targetingIntroductionLarge-scale multiplexed imaging and gene perturbation technologies have transformed mammalian cell biology but are predominantly limited to nucleic acids. This is due to the ease of generating specific targeting reagents via sequence complementarity, which does not extend to the proteins.