George S. Vassiliou

Jan 17, 2024 | nature.com | Jing Guo |Klaudia Walter |Paola Guglielmelli |George S. Vassiliou |Jyoti Nangalia

AbstractMyeloproliferative neoplasms (MPNs) are chronic cancers characterized by overproduction of mature blood cells. Their causative somatic mutations, for example, JAK2V617F, are common in the population, yet only a minority of carriers develop MPN. Here we show that the inherited polygenic loci that underlie common hematological traits influence JAK2V617F clonal expansion. We identify polygenic risk scores (PGSs) for monocyte count and plateletcrit as new risk factors for JAK2V617F positivity.

May 4, 2023 | nejm.org | George S. Vassiliou |Elizabeth G. Phimister

During cell division, the DNA-replication machinery generates a copy of each chromosome.