Paola Guglielmelli

1 month ago | onlinelibrary.wiley.com | Natasha Szuber |Paola Guglielmelli |Naseema Gangat

1 Introduction Sex has been identified as a key regulator of susceptibility to cancer, response to therapy, disease outcomes, and associated mortality [1]. The mechanisms underpinning sex-biased disparities include distinct genetic profiles [2], hormone patterns [3], immune responses [4], and drug metabolism [5].

Nov 5, 2024 | nature.com | Tiziano Barbui |Alessandra Carobbio |Alessandro Vannucchi |Paola Guglielmelli |Alessandro Rambaldi |Naseema Gangat

AbstractWe analyzed the neutrophil-to-lymphocyte ratio (NLR) in 1508 patients with PV and found that those with an NLR ≥ 5 were generally older, had a longer disease history, and had higher cardiovascular risk factors, more arterial thrombosis, and more aggressive blood counts, indicating a more proliferative disease.

Oct 7, 2024 | onlinelibrary.wiley.com | Tiziano Barbui |Alessandra Carobbio |Paola Guglielmelli |Arianna Ghirardi

CONFLICT OF INTEREST STATEMENT No conflicts of interest were declared. Supporting Information Filename Description bjh19813-sup-0001-TableS1.docxWord 2007 document , 27.8 KB Table S1. REFERENCES 1, , , , , , et al. International consensus classification of myeloid neoplasms and acute leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022; 140: 1200–1228. 2, , , , , , et al.

Apr 21, 2024 | nature.com | Alessandra Carobbio |Paola Guglielmelli |Valerio De Stefano |Ayalew Tefferi

TO THE EDITOR:Over the past decade, observational and population-based studies have documented an excess of solid tumors and lymphomas in patients with myeloproliferative neoplasms (MPN), including polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF), but the causes of this excess remain elusive [1,2,3].

Jan 17, 2024 | nature.com | Jing Guo |Klaudia Walter |Paola Guglielmelli |George S. Vassiliou |Jyoti Nangalia

AbstractMyeloproliferative neoplasms (MPNs) are chronic cancers characterized by overproduction of mature blood cells. Their causative somatic mutations, for example, JAK2V617F, are common in the population, yet only a minority of carriers develop MPN. Here we show that the inherited polygenic loci that underlie common hematological traits influence JAK2V617F clonal expansion. We identify polygenic risk scores (PGSs) for monocyte count and plateletcrit as new risk factors for JAK2V617F positivity.