Georgios Skiniotis

Mar 19, 2024 | biorxiv.org | Laura Shub |Wenjin Liu |Georgios Skiniotis |Michael Keiser

AbstractAt sufficiently high resolution, x-ray crystallography and cryogenic electron microscopy are capable of resolving small spherical map features corresponding to either water or ions. Correct classification of these sites provides crucial insight for understanding structure and function as well as guiding downstream design tasks, including structure-based drug discovery and de novo biomolecule design.