Gerhard Hummer

Sep 11, 2024 | biorxiv.org | Gerhard Hummer

AbstractIn selective autophagy, cargo recruitment is mediated by LC3-interacting regions (LIRs)/Atg8-interacting motifs (AIMs) in the cargo or cargo receptor proteins. The binding of these motifs to LC3/Atg8 proteins at the phagophore membrane is often modulated by post-translational modifications, especially phosphorylation. As a challenge for computational LIR predictions, sequences may contain the short canonical (W/F/Y)XX(L/I/V) motif without being functional.

Apr 24, 2023 | nature.com | Sonja Welsch |Gerhard Hummer

AbstractIron-bound cyclic tetrapyrroles (hemes) are redox-active cofactors in bioenergetic enzymes. However, the mechanisms of heme transport and insertion into respiratory chain complexes remain unclear. Here, we used cellular, biochemical, structural and computational methods to characterize the structure and function of the heterodimeric bacterial ABC transporter CydDC.