Sonja Welsch

Jun 5, 2024 | nature.com | Iskander Khusainov |Camille V. Goemans |Christian Zimmerli |Sonja Welsch |Julian D. Langer |Athanasios Typas

AbstractRibosomes translate the genetic code into proteins. Recent technical advances have facilitated in situ structural analyses of ribosome functional states inside eukaryotic cells and the minimal bacterium Mycoplasma. However, such analyses of Gram-negative bacteria are lacking, despite their ribosomes being major antimicrobial drug targets. Here we compare two E. coli strains, a lab E. coli K-12 and human gut isolate E.

Apr 24, 2023 | nature.com | Sonja Welsch |Gerhard Hummer

AbstractIron-bound cyclic tetrapyrroles (hemes) are redox-active cofactors in bioenergetic enzymes. However, the mechanisms of heme transport and insertion into respiratory chain complexes remain unclear. Here, we used cellular, biochemical, structural and computational methods to characterize the structure and function of the heterodimeric bacterial ABC transporter CydDC.