Gillian Meeks

Aug 26, 2024 | biorxiv.org | Gillian Meeks |Brooke Scelza |Sean P. Prall |Hana M Asnake

AbstractAging is associated with genome-wide changes in DNA methylation in humans, facilitating the development of epigenetic age prediction models. However, most of these models have been trained primarily on European-ancestry individuals, and none account for the impact of methylation quantitative trait loci (meQTL).

Aug 15, 2024 | digitalcommons.library.tmc.edu | Rachel Mester |Kangcheng Hou |Yi Ding |Gillian Meeks

Publication Date6-1-2023JournalAmerican Journal of Human GeneticsAbstractGenome-wide association studies (GWASs) have identified thousands of variants for disease risk. These studies have predominantly been conducted in individuals of European ancestries, which raises questions about their transferability to individuals of other ancestries. Of particular interest are admixed populations, usually defined as populations with recent ancestry from two or more continental sources.

Dec 20, 2023 | nature.com | Gillian Meeks |Shyamalika Gopalan

Introductionarising from B. Li et al. Communications Biology https://doi.org/10.1038/s42003-022-03353-5 (2022)DNA methylation variation broadly mirrors genetic variation, capturing population-level patterns that largely reflect global geography1,2,3,4; however, little is known about how genetic admixture shapes these relationships (but see refs. 5,6). To address this gap, Li et al.

Sep 11, 2023 | biorxiv.org | Austin Reynolds |Haiko Schurz |Gillian Meeks |Simon Gravel

AbstractThe colonial-period arrival of Europeans in southern Africa is associated with strong sex-biased migration by which male settlers displaced indigenous Khoekhoe and San men. Simultaneously, the importation of South Asian, Indonesian and Eastern African slaves may have contributed female-biased migration to Cape Town and surrounding areas.