Kangcheng Hou

Aug 15, 2024 | digitalcommons.library.tmc.edu | Rachel Mester |Kangcheng Hou |Yi Ding |Gillian Meeks

Publication Date6-1-2023JournalAmerican Journal of Human GeneticsAbstractGenome-wide association studies (GWASs) have identified thousands of variants for disease risk. These studies have predominantly been conducted in individuals of European ancestries, which raises questions about their transferability to individuals of other ancestries. Of particular interest are admixed populations, usually defined as populations with recent ancestry from two or more continental sources.

Aug 15, 2024 | digitalcommons.library.tmc.edu | Kangcheng Hou |Yi Ding |Ziqi Xu |Yue Wu

Individuals of admixed ancestries (for example, African Americans) inherit a mosaic of ancestry segments (local ancestry) originating from multiple continental ancestral populations. This offers the unique opportunity of investigating the similarity of genetic effects on traits across ancestries within the same population.

Jun 17, 2024 | nature.com | Kangcheng Hou |Arbel Harpak

AbstractPolygenic scores (PGS) have emerged as the tool of choice for genomic prediction in a wide range of fields. We show that PGS performance varies broadly across contexts and biobanks. Contexts such as age, sex and income can impact PGS accuracy with similar magnitudes as genetic ancestry.

Jul 27, 2023 | medrxiv.org | Kangcheng Hou |Ziqi Xu |Yi Ding |Arbel Harpak

AbstractPolygenic scores (PGS) have emerged as the tool of choice for genomic prediction in a wide range of fields from agriculture to personalized medicine. We analyze data from two large biobanks in the US (All of Us) and the UK (UK Biobank) to find widespread variability in PGS performance across contexts. Many contexts, including age, sex, and income, impact PGS accuracies with similar magnitudes as genetic ancestry.