Ginger E. Nicol

Oct 15, 2024 | nature.com | Dean F. Wong |Ginger E. Nicol

AbstractRegulation of dopamine activity has important clinical consequences, most notably in schizophrenia. LB-102, N-methyl amisulpride, is a novel dopamine D2/3/5-HT7 inhibitor being developed as a treatment for schizophrenia and other psychiatric disorders. The characteristic that is common to all current antipsychotics is their engagement of D2 dopamine receptors.

Feb 13, 2024 | biologicalpsychiatryjournal.com | Joshua Siegel |Subha Subramanian |Nico U.F. Dosenbach |Ginger E. Nicol

A single dose of psilocybin has been shown to have persistent antidepressant effects in human clinical trials. In animal models, psilocybin induces neuroplasticity in cortex and hippocampus. Deciphering the acute and persistent effects of psilocybin on the human brain is a critical step towards better understanding the neurobiology of psychedelics.

Jul 24, 2023 | jamanetwork.com | Simone A. Bernstein |Alison L. Huckenpahler |Ginger E. Nicol |Jessica Gold

Introduction The COVID-19 pandemic led to a global mental health crisis,1 with increased mental health–related visits across specialties and emergency departments.2,3 This study aims to quantify this increase by comparing prepandemic and postpandemic patient messaging in psychiatry. With inbox electronic health records (EHRs) volume as the main outcome, we hypothesized an increase in postpandemic messages.