Giuseppe Blasi

Mar 13, 2023 | nature.com | Dongjing Liu |Brian K. Fennessy |Esther Cheng |Joseph D. Buxbaum |Enrico Domenici |Dheeraj Malhotra | +21 more

AbstractSchizophrenia (SCZ) is a chronic mental illness and among the most debilitating conditions encountered in medical practice. A recent landmark SCZ study of the protein-coding regions of the genome identified a causal role for ten genes and a concentration of rare variant signals in evolutionarily constrained genes1.

Feb 17, 2023 | nature.com | Giulio Pergola |Enrico D’Ambrosio |Giuseppe Blasi

Sample determinationA total of 546 individuals, all Caucasians native of the Apulia region, Italy, participated in the study. Inclusion and exclusion criteria and full details about sample determination are reported in SII, Section 1. Specifically, our sample included 290 HC and 177 patients, of which 118 were SCZ and 59 were BD, according to the Diagnostic and Statistical Manual of Mental Diseases-5 criteria3.