Enrico D’Ambrosio

Apr 30, 2024 | nature.com | Leonardo Sportelli |Daniel Eisenberg |Enrico D’Ambrosio |Michael Gregory |Thomas Hyde |Joel E. Kleinman | +6 more

AbstractThe polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decomposition, we analyze gene co-expression in the caudate nucleus, hippocampus, and dorsolateral prefrontal cortex of post-mortem brain samples from 358 individuals.

Feb 17, 2023 | nature.com | Giulio Pergola |Enrico D’Ambrosio |Giuseppe Blasi

Sample determinationA total of 546 individuals, all Caucasians native of the Apulia region, Italy, participated in the study. Inclusion and exclusion criteria and full details about sample determination are reported in SII, Section 1. Specifically, our sample included 290 HC and 177 patients, of which 118 were SCZ and 59 were BD, according to the Diagnostic and Statistical Manual of Mental Diseases-5 criteria3.