Gloria Asantewaa

Jul 20, 2024 | nature.com | Gloria Asantewaa |Nathan P. Ward |Yun Pyo Kang |Yumi Kim |Nomeda Girnius |Fabio Hecht | +11 more

AbstractCells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many diseases, but the requirement for GSH in adult tissues is unclear. To interrogate this, we have developed a series of in vivo models to induce Gclc deletion in adult animals. We find that GSH is essential to lipid abundance in vivo.