Nomeda Girnius

Nov 11, 2024 | nature.com | Carman Man-Chung Li |Francesca Silvestri |Nomeda Girnius |Aviv Regev |Alyssa Cordes |S. Cigall Kadoch

AbstractGermline BRCA1 mutation carriers face a high breast cancer risk; however, the underlying mechanisms for this risk are not completely understood. Using a new genetically engineered mouse model of germline Brca1 heterozygosity, we demonstrate that early tumor onset in a Brca1 heterozygous background cannot be fully explained by the conventional ‘two-hit’ hypothesis, suggesting the existence of inherent tumor-promoting alterations in the Brca1 heterozygous state.

Jul 20, 2024 | nature.com | Gloria Asantewaa |Nathan P. Ward |Yun Pyo Kang |Yumi Kim |Nomeda Girnius |Fabio Hecht | +11 more

AbstractCells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many diseases, but the requirement for GSH in adult tissues is unclear. To interrogate this, we have developed a series of in vivo models to induce Gclc deletion in adult animals. We find that GSH is essential to lipid abundance in vivo.