Gorka Garay

Apr 12, 2023 | onlinelibrary.wiley.com | Lorena Garcia |Gorka Garay |Josebe Hurtado |Manuel Pedrón

Graphical Abstract 2-Alkenyl-substituted cyclopropylacetaldehydes undergo enantioselective vinylcyclopropane-cyclopentene (VCP-CP) rearrangement using a Jorgensen-Hayashi-type catalyst. The reaction proceeds through enamine/iminium activation and comprises the in situ generation of a donor-acceptor cyclopropane intermediate that undergoes ring-opening/cyclization. Computational studies together with the experimental data support a type-II DYKAT process operating.