Manuel Pedrón

Nov 27, 2023 | onlinelibrary.wiley.com | Manuel Pedrón |Laura Villar |Uxue Uria |Liher Prieto

Introduction Cycloaddition reactions represent one of the most efficient and direct approach for the synthesis of cyclic molecules.1 This type of transformations not only enable the direct construction of the cyclic target in a single step through the reaction between two components involving the consecutive formation of at least two new C−C or C-heteroatom bonds, but also allow for an exquisite degree of selectivity when generating complex molecular scaffolds with multiple stereogenic...

Oct 2, 2023 | pubs.acs.org | Esteban Matador |Michael J. Tilby |Iakovos Saridakis |Manuel Pedrón

Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2023, XXXX, XXXCCDC 2298765 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing [email protected], or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033.

Oct 2, 2023 | dx.doi.org | Esteban Matador |Michael J. Tilby |Manuel Pedrón |Iakovos Saridakis

Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Am. Chem. Soc. 2023, XXXX, XXXCCDC 2298765 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing [email protected], or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033.

Apr 12, 2023 | onlinelibrary.wiley.com | Lorena Garcia |Gorka Garay |Josebe Hurtado |Manuel Pedrón

Graphical Abstract 2-Alkenyl-substituted cyclopropylacetaldehydes undergo enantioselective vinylcyclopropane-cyclopentene (VCP-CP) rearrangement using a Jorgensen-Hayashi-type catalyst. The reaction proceeds through enamine/iminium activation and comprises the in situ generation of a donor-acceptor cyclopropane intermediate that undergoes ring-opening/cyclization. Computational studies together with the experimental data support a type-II DYKAT process operating.