Gregory Linshiz

Aug 30, 2024 | biorxiv.org | Simeon D. Castle |Adrian Woolfson |Blake T. Riley |Gregory Linshiz

AbstractDNA polymerases are complex molecular machines able to replicate genetic material using a template-driven process. While the copying function of these enzymes is well established, their ability to perform untemplated DNA synthesis is less well characterized. Here, we explore the ability of DNA polymerases to synthesize DNA fragments in the absence of template.