Gregory Nemet

May 9, 2024 | pnas.org | Harry Gray |Morgan Edwards |Zachary Thomas |Gregory Nemet

A. A. T. Naqvi et al., Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach. Biochim. Biophys. Acta Mol. Basis Dis. 1866, 165878 (2020). M. Thoms et al., Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science 369, 1249–1255 (2020). R. Yadav et al., Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19. Cells 10, 821 (2021). M. A. Rohaim, R. F. El Naggar, E.

May 9, 2024 | pnas.org | Morgan Edwards |Zachary Thomas |Gregory Nemet |Sagar Rathod

SignificanceThe physical pairing of chromosomes with their homologs is the basis of Mendelian genetics, but how chromosomes find each other is poorly understood, especially in cases where homolog pairing does not involve breaks in the DNA. We used a polymer model of chromosomes to show that adhesive patches, if distributed in a bar-code pattern, can produce selective homolog pairing even if every patch has the ability to bind any other patch with the same force.

May 8, 2024 | pnas.org | Morgan Edwards |Zachary Thomas |Gregory Nemet |Sagar Rathod

G. A. Parker, J. Maynard Smith, Evolution and the Theory of Games (Cambridge University Press, 1982). J. W. Stephens, J. R. Krebs, Foraging Theory (Princeton University Press, Princeton NJ, 1986). J. von Neumann, O. Morgenstern, The Theory of Games and Economic Behavior (Princeton University Press, Princeton, 1944). D. Kahneman, A. Tversky, Prospect theory: An analysis of decision under risk. Econometrica 47, 263–291 (1979). K. Samejima, Y. Ueda, K. Doya, M.

May 8, 2024 | pnas.org | Morgan Edwards |Zachary Thomas |Gregory Nemet |Sagar Rathod

DNA lesion bypass and the stochastic dynamics of transcription-coupled repairEdited by Aziz Sancar, The University of North Carolina at Chapel Hill, Chapel Hill, NC; received February 23, 2024; accepted April 9, 2024SignificanceDamage to DNA can interfere with crucial cellular processes such as the transcription of genes into RNA and can ultimately lead to mutations, DNA sequence changes, that are inherited by subsequent generations of cells and organisms.

May 8, 2024 | pnas.org | Morgan Edwards |Zachary Thomas |Gregory Nemet |Sagar Rathod

A mechanistic model of gossip, reputations, and cooperationEdited by Brian Skyrms, University of California, Irvine, CA; received January 12, 2024; accepted April 12, 2024SignificanceThose who help others may earn good reputations, making them more likely to receive help themselves. This feedback loop—called indirect reciprocity—fosters cooperation provided people agree on who is in good or bad standing. Gossip has long been thought to produce such agreement.