Gregory R. Keele

1 month ago | biorxiv.org | Gregory R. Keele |Monika Dzieciatkowska |Ariel Hay |Matthew Vincent

AbstractRed blood cells (RBCs) transport oxygen but accumulate oxidative damage over time, reducing function in vivo and during storage - critical for transfusions. To explore genetic influences on RBC resilience, we profiled proteins, metabolites, and lipids from fresh and stored RBCs obtained from 350 genetically diverse mice. Our analysis identified over 6,000 quantitative trait loci (QTL).

Apr 25, 2024 | journals.plos.org | Gregory R. Keele |Whitney Martin |Timothy Stodola |Callan O’Connor

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: O’Connor C, Keele GR, Martin W, Stodola T, Gatti D, Hoffman BR, et al. (2024) Unraveling the genetics of arsenic toxicity with cellular morphology QTL. PLoS Genet 20(4): e1011248. https://doi.org/10.1371/journal.pgen.1011248Editor: Kent W.

Nov 18, 2023 | biorxiv.org | Gregory R. Keele |Whitney Martin |Callan O'Connor |Timothy Stodola

AbstractGenetically heterogenous cell lines from laboratory mice are promising tools for population-based screening as they offer power for genetic mapping, and potentially, predictive value for in vivo experimentation in genetically matched individuals. To explore this further, we derived a panel of fibroblast lines from a genetic reference population of laboratory mice (the Diversity Outbred, DO).