Monika Dzieciatkowska

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Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione pools

1 month ago | biorxiv.org | Gregory R. Keele |Monika Dzieciatkowska |Ariel Hay |Matthew Vincent

AbstractRed blood cells (RBCs) transport oxygen but accumulate oxidative damage over time, reducing function in vivo and during storage - critical for transfusions. To explore genetic influences on RBC resilience, we profiled proteins, metabolites, and lipids from fresh and stored RBCs obtained from 350 genetically diverse mice. Our analysis identified over 6,000 quantitative trait loci (QTL).

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