Guang S. He

Oct 10, 2024 | dx.doi.org | Sonal Gupta |Guang S. He |Vivek Kumar |Martin Trebbin

C: Spectroscopy and Dynamics of Nano, Hybrid, and Low-Dimensional MaterialsOctober 10, 2024Sonal GuptaDepartment of Chemistry, University at Buffalo, SUNY, New York 14260, United StatesThe Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, SUNY, New York 14260, United StatesGuang S.

Sep 26, 2024 | nature.com | Xi Zheng |Guang S. He |Yi Shi

AbstractComputational models have made significant progress in predicting the effect of protein variants. However, deciphering numerous variants of uncertain significance (VUS) located within intrinsically disordered regions (IDRs) remains challenging. To address this issue, we introduce phase separation, which is tightly linked to IDRs, into the investigation of missense variants. Phase separation is vital for multiple physiological processes.