Guanghou Shui

Nov 11, 2024 | nature.com | Peng Hu |Guanghou Shui

AbstractAlthough the metabolism of yolk lipids such as docosahexaenoic acid (DHA) is pivotal for embryonic development, the underlying mechanism remains elusive. Here we find that the zebrafish hydroxysteroid (17-β) dehydrogenase 12a (hsd17b12a), which encodes an intestinal epithelial-specific enzyme, is essential for the biosynthesis of long-chain polyunsaturated fatty acids in primitive intestine of larval fish.

Oct 2, 2024 | nature.com | Bo Burla |Makoto Arita |Takeshi Bamba |Britta Brügger |Benoit Colsch |Alex Dickens | +29 more

AbstractIn this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry four clinically used ceramide species in the NIST (National Institute of Standards and Technology) human blood plasma Standard Reference Material (SRM) 1950, as well as a set of candidate plasma reference materials (RM 8231).

Sep 29, 2023 | nature.com | Guanghou Shui |Zhihui Zhang

AbstractPost-translational modifications (PTMs) couple feed-fast cycles to diurnal rhythms. However, it remains largely uncharacterized whether and how meal timing organizes diurnal rhythms beyond the transcriptome.

Jun 26, 2023 | nature.com | He Tian |Guanghou Shui |Zhihui Zhang

AbstractPhysical endurance and energy conservation are essential for survival in the wild. However, it remains unknown whether and how meal timing regulates physical endurance and muscle diurnal rhythms. Here, we show that day/sleep time-restricted feeding (DRF) enhances running endurance by 100% throughout the circadian cycle in both male and female mice, compared to either ad libitum feeding or night/wake time-restricted feeding.