Zhihui Zhang

Sep 2, 2024 | nature.com | Lu Wang |Yujie Zhang |Caihong Wang |Yayuan Chen |Qian Qian |Nannan Zhang | +9 more

Depression, a widespread and highly heritable mental health condition, profoundly affects millions of individuals worldwide. Neuroimaging studies have consistently revealed volumetric abnormalities in subcortical structures associated with depression. However, the genetic underpinnings shared between depression and subcortical volumes remain inadequately understood. Here, we investigate the extent of polygenic overlap using the bivariate causal mixture model (MiXeR), leveraging summary statistics from the largest genome-wide association studies for depression (N = 674,452) and 14 subcortical volumetric phenotypes (N = 33,224). Additionally, we identify shared genomic loci through conditional/conjunctional FDR analyses. MiXeR shows that subcortical volumetric traits share a substantial proportion of genetic variants with depression, with 44 distinct shared loci identified by subsequent conjunctional FDR analysis. These shared loci are predominantly located in intronic regions (58.7%) and non-coding RNA intronic regions (25.4%). The 269 protein-coding genes mapped by these shared loci exhibit specific developmental trajectories, with the expression level of 55 genes linked to both depression and subcortical volumes, and 30 genes linked to cognitive abilities and behavioral symptoms. These findings highlight a shared genetic architecture between depression and subcortical volumetric phenotypes, enriching our understanding of the neurobiological underpinnings of depression. Depression affects millions of people worldwide. Here, the authors show a substantial polygenic overlap between depression and brain subcortical volumes, identifying 44 shared loci.

May 6, 2024 | dialnet.unirioja.es | Zhihui Zhang

Forelimb Myology of the Golden Pheasant (Chrysolophus pictus)Zihui Zhang[1];Yan Yang[1][1]Capital Normal University College of Life SciencesLocalización: International Journal of morphology, ISSN-e 0717-9502, Vol. 31, Nº. 4, 2013, págs.

Sep 29, 2023 | nature.com | Guanghou Shui |Zhihui Zhang

AbstractPost-translational modifications (PTMs) couple feed-fast cycles to diurnal rhythms. However, it remains largely uncharacterized whether and how meal timing organizes diurnal rhythms beyond the transcriptome.

Sep 29, 2023 | ascpt.onlinelibrary.wiley.com | Abdul Wahid |Juan Wen |Qiong Yang |Zhihui Zhang

WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? An observational case–control study was conducted, including 157 patients and 50 healthy controls. Of the patients, 55 had acute myocardial infarction (AMI) without heart failure (HF; AMI−HF), 42 had AMI with HF (AMI+HF), and 60 had HF without AMI (HF−AMI). The high mobility group box 1 (HMGB1) is an active biochemical factor early started to increase in the blood of patients with AMI−HF and can be used as a biomarker of AMI−HF.

Jul 30, 2023 | mdpi.com | Zhenzhen Wang |Junfeng Qian |Zhonghua Sun |Zhihui Zhang

Abstract:H2 has aroused significant attention as an unpolluted and renewable energy carrier. However, the efficient storage and controllable release of H2 are urgent to be addressed. Through the hydrogenation of CO2 (bicarbonate) to produce formic acid (formate) and reverse dehydrogenation reactions, a carbon-neutral formic acid-based hydrogen cycle system can be established.