Guanghua Xiao

Oct 27, 2024 | biorxiv.org | Lin Zhong |Siyuan Zhang |Qiwei Li |Guanghua Xiao

AbstractT cells are the central players in antitumor immunity, and effective tumor killing depends on their ability to infiltrate into the tumor microenvironment (TME) while maintaining normal cytotoxicity. However, late-stage tumors develop immunosuppressive mechanisms that impede T cell movement and induce exhaustion. Investigating T cell migration in human tumors in vivo could provide novel insights into tumor immune escape, although it remains a challenging task.