Guillaume Dolla

Jun 17, 2024 | jbc.org | Université Côte d'Azur |Sophia Antipolis |Sarah Nicolas |Guillaume Dolla

ABSTRACTPhospholipase A2 receptor 1 (PLA2R1) is a 180-kDa transmembrane protein that plays a role in inflammation and cancer, and is the major autoantigen in membranous nephropathy (MN), a rare but severe autoimmune kidney disease. A soluble form of PLA2R1 has been detected in mouse and human serum. It is likely produced by proteolytic shedding of membrane-bound PLA2R1 but the mechanism is unknown.