Gunnar K. Gouras

Dec 6, 2024 | cell.com | Rudy Jacquet |Fernando González Ibanez |Katherine Picard |Lucy Funes |Gunnar K. Gouras |Marie-Eve Tremblay | +3 more

Keywords Alzheimer’s disease digestive exophagy microglia lysosome amyloid-beta extracellular degradation acid phosphatase electron microscopy 5xFAD lysosomal pH Research topic(s) CP: Neuroscience Introduction Alzheimer’s disease (AD) is a neurodegenerative condition generally associated with the accumulation of large aggregates of amyloid-beta (Aβ) in the brain.1 Microglia, the immune cells of the central nervous system (CNS), maintain brain homeostasis by phagocytosing apoptotic cells,2...