Fernando González Ibanez

Dec 23, 2024 | cell.com | Anna Flury |Leen Aljayousi |Hye-Jin Park |Mohammadparsa Khakpour |Jack Mechler |Siaresh Aziz | +10 more

1Neuroscience Initiative, Advanced Science Research Center, The City University of New York (CUNY) Graduate Center, New York, NY 10031, USA 2Graduate Program in Biology, CUNY Graduate Center, New York, NY 10016, USA 3Division of Medical Sciences, University of Victoria, Victoria, BC V8P 5C4, Canada 4Graduate Program in Biochemistry, CUNY Graduate Center, New York, NY 10016, USA 5Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Michigan Medicine, Ann...

Dec 6, 2024 | cell.com | Rudy Jacquet |Fernando González Ibanez |Katherine Picard |Lucy Funes |Gunnar K. Gouras |Marie-Eve Tremblay | +3 more

Keywords Alzheimer’s disease digestive exophagy microglia lysosome amyloid-beta extracellular degradation acid phosphatase electron microscopy 5xFAD lysosomal pH Research topic(s) CP: Neuroscience Introduction Alzheimer’s disease (AD) is a neurodegenerative condition generally associated with the accumulation of large aggregates of amyloid-beta (Aβ) in the brain.1 Microglia, the immune cells of the central nervous system (CNS), maintain brain homeostasis by phagocytosing apoptotic cells,2...