Guohao Yuan

Dec 9, 2024 | nature.com | Zhong Lin Wang |Guohao Yuan |Wei Yan |Kai Yuan |Yanping Bao |Jie Shi | +3 more

AbstractSleep interacts reciprocally with the gut microbiota. However, mechanisms of the gut microbe-brain metabolic axis that are responsible for sleep behavior have remained largely unknown. Here, we showed that the absence of the gut microbiota can alter sleep behavior. Sleep deprivation reduced butyrate levels in fecal content and the hypothalamus in specific pathogen-free mice but not in germ-free mice.