Gurumurthy Hiremath

Oct 15, 2024 | nature.com | Zeeshan Syedain |Gurumurthy Hiremath |John Carney |Andrea Rivera |John Mayer |Zhitian Shi

AbstractGrowth is the holy grail of tissue implants in pediatrics. No vascular graft currently in use for surgical repairs of congenital heart defects has somatic growth capacity. Biologically-engineered grafts (6 mm) grown from donor ovine fibroblasts in a sacrificial fibrin gel were implanted into the left pulmonary branch of 3-month old lambs for 3, 6, and 18 months. A control group of Propaten® PTFE grafts was implanted for 6 months.