Gustavo Deco

1 month ago | nature.com | Juan Piccinini |Yonatan Sanz Perl |Gustavo Deco |Morten L. Kringelbach |David Nutt

AbstractThe transition towards the brain state induced by psychedelic drugs is frequently neglected in favor of a static description of their acute effects. We use a time-dependent whole-brain model to reproduce large-scale brain dynamics measured with fMRI from 15 volunteers under 20 mg intravenous N,N-Dimethyltryptamine (DMT), a short-acting psychedelic. To capture its transient effects, we parametrize the proximity to a global bifurcation using a pharmacokinetic equation.

Dec 2, 2024 | mdpi.com | Marta Xavier |Patrícia Figueiredo |Gustavo Deco |Andrea Luppi

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Jul 24, 2024 | biorxiv.org | Priyanka Chakraborty |Suman Krishna Saha |Gustavo Deco |Arpan Banerjee

AbstractBrain function is shaped by the local and global connections between its dynamical units and biological parameters. With aging, the anatomical connectivity undergoes significant deterioration (e.g., long-range white matter fiber loss), which affects the brain's overall function. Despite the structural loss, previous research has shown that normative patterns of functions remain intact across the lifespan, defined as the compensatory mechanism of the aging brain.

Apr 17, 2023 | nature.com | Gustavo Deco

AbstractFast, efficient information transfer is essential for the brain to ensure survival. As recently shown in functional magnetic resonance imaging with high spatial resolution, turbulence appears to offer a fundamental way to facilitate energy and information transfer across spatiotemporal scales in brain dynamics.