Yonatan Sanz Perl

1 month ago | nature.com | Juan Piccinini |Yonatan Sanz Perl |Gustavo Deco |Morten L. Kringelbach |David Nutt

AbstractThe transition towards the brain state induced by psychedelic drugs is frequently neglected in favor of a static description of their acute effects. We use a time-dependent whole-brain model to reproduce large-scale brain dynamics measured with fMRI from 15 volunteers under 20 mg intravenous N,N-Dimethyltryptamine (DMT), a short-acting psychedelic. To capture its transient effects, we parametrize the proximity to a global bifurcation using a pharmacokinetic equation.