Gustavo Turecki

Oct 11, 2024 | nature.com | Lena C Quilty |Pierre Blier |Jane Foster |Stefan Kloiber |Raymond W. Lam |Daniel Muller | +4 more

AbstractCurrent pharmacological agents for depression have limited efficacy in achieving remission. Developing and validating new medications is challenging due to limited biological targets. This study aimed to link electrophysiological data and symptom improvement to better understand mechanisms underlying treatment response.

Apr 8, 2024 | nature.com | Gustavo Turecki

AbstractMajor depressive disorder (MDD) is a complex and potentially debilitating illness whose etiology and pathology remains unclear. Non-coding RNAs have been implicated in MDD, where they display differential expression in the brain and the periphery. In this study, we quantified small nucleolar RNA (snoRNA) expression by small RNA sequencing in the lateral habenula (LHb) of individuals with MDD (n = 15) and psychiatrically-healthy controls (n = 15).

Feb 15, 2024 | nature.com | Anna R. Docherty |Gustavo Turecki

AbstractPrior studies have suggested an association between chronic pain and suicidal behavior. However, evidence supporting the causal nature of this association, and the role played by depression, remain difficult to establish due to confounding. We investigated associations of chronic pain with suicide attempt and death by suicide as well as the mediating role of depression in this association using a genetically informed method strengthening causal inference.

Apr 27, 2023 | nature.com | Gustavo Turecki

AbstractSchizophrenia is a disabling disorder involving genetic predisposition in combination with environmental influences that likely act via dynamic alterations of the epigenome and the transcriptome but its detailed pathophysiology is largely unknown. We performed cell-type specific methylome-wide association study of neonatal blood (N = 333) from individuals who later in life developed schizophrenia and controls.