Anna R. Docherty

Oct 20, 2024 | nature.com | Kyle Sullivan |Matthew Lane |Mirko Pavicic |Xuejun Qin |Niamh Mullins |Anna R. Docherty | +6 more

AbstractGenome-wide association studies (GWAS) identify genetic variants underlying complex traits but are limited by stringent genome-wide significance thresholds. We present GRIN (Gene set Refinement through Interacting Networks), which increases confidence in the expanded gene set by retaining genes strongly connected by biological networks when GWAS thresholds are relaxed. GRIN was validated on both simulated interrelated gene sets as well as multiple GWAS traits.

Jul 30, 2024 | digitalcommons.library.tmc.edu | Enda M. Byrne |Anna R. Docherty |Niamh Mullins |Allison Ashley-Koch

OBJECTIVE: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date.

Feb 22, 2024 | nature.com | Brenda Cabrera-Mendoza |Gabriel R. Fries |Anna R. Docherty

AbstractBipolar disorder (BD) and schizophrenia (SZ) are associated with higher odds of suicide attempt (SA). In this study, we aimed to explore the effect of BD and SZ genetic liabilities on SA, also considering the contribution of behavioral traits, socioeconomic factors, and substance use disorders.

Feb 15, 2024 | nature.com | Anna R. Docherty |Gustavo Turecki

AbstractPrior studies have suggested an association between chronic pain and suicidal behavior. However, evidence supporting the causal nature of this association, and the role played by depression, remain difficult to establish due to confounding. We investigated associations of chronic pain with suicide attempt and death by suicide as well as the mediating role of depression in this association using a genetically informed method strengthening causal inference.

Oct 1, 2023 | ajp.psychiatryonline.org | Enda M. Byrne |Anna R. Docherty |Niamh Mullins |Allison Ashley-Koch

Suicide accounted for more than 700,000 deaths worldwide in 2019 and was the fourth leading cause of death among 15- to 29-year-olds (1). Suicide attempt is even more common (2–4). Suicide attempt is strongly associated with psychiatric conditions, poor quality of life, traumatic experiences, and social and economic burden (1) and is the single strongest predictor of future suicide death (5).